Aging-driven metabolic abnormalities remodel intercellular communication through the gut–liver–heart axis and may promote coronary artery disease: the key role of bile acid metabolism - Takeaways - MDSpire
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Metabolic Changes Associated with Aging Alter Intercellular Interactions via the Gut–Liver–Heart Axis and May Contribute to Coronary Artery Disease: The Critical Function of Bile Acid Metabolism

  • By

  • Wei Chen

  • Yue Sun

  • Chu-fan Meng

  • Si-tong Wu

  • Xin-yi Jiang

  • Xian-meng Meng

  • Qing-feng Wang

  • July 6, 2026

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  • 1

    Coronary artery disease (CAD) is the leading cause of cardiovascular mortality, with prevalence increasing significantly in older adults.

  • 2

    Aging contributes to CAD through mechanisms like cellular senescence and the senescence-associated secretory phenotype (SASP), promoting chronic inflammation.

  • 3

    Endothelial dysfunction and large-artery stiffness are key vascular phenotypes of aging, independently predicting future cardiovascular events.

  • 4

    Gut microbiota dysbiosis and altered bile acid metabolism are linked to CAD, affecting systemic inflammation and cardiovascular health.

  • 5

    The gut, liver, and heart form a communication network that influences cardiovascular outcomes, highlighting the importance of multi-organ interactions.

Original Source(s)

Aging-driven metabolic abnormalities remodel intercellular communication through the gut–liver–heart axis and may promote coronary artery disease: the key role of bile acid metabolism

  • by Wei Chen, Yue Sun, Chu-fan Meng, Si-tong Wu, Xin-yi Jiang, Xian-meng Meng, Qing-feng Wang

  • July 6, 2026

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