The consequences of antipsychotic medication use for people living with dementia: a systematic review and meta-analysis

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Antipsychotic drugs are frequently prescribed to manage behavioral and psychological symptoms in individuals with dementia, despite safety concerns.
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This systematic review included 45 studies with over two million participants, revealing a significant increase in mortality risk associated with antipsychotic use.
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Subgroup analysis indicated that both typical and atypical antipsychotics elevate mortality risk, particularly among community-dwelling individuals.
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Evidence for other adverse outcomes, such as stroke and pneumonia, was limited and heterogeneous, though some studies indicated elevated risks.
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The findings highlight the need for cautious prescribing, regular medication reviews, and close monitoring of individuals with dementia.

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