HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion - Takeaways - MDSpire
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Moderately Differentiated Squamous Cell Carcinoma of the Cervix Associated with HPV: A Case of Bladder Invasion and Suspected Adrenal Metastasis in a Patient with Previous Lung Adenocarcinoma Surgery

  • By

  • Yaxiong Tang

  • Yanbo Dai

  • Min Jing

  • Kang Wang

  • July 10, 2026

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  • 1

    Cervical squamous cell carcinoma (CSCC) can present with urinary symptoms due to bladder invasion, complicating diagnosis and treatment.

  • 2

    A 74-year-old woman with a history of lung adenocarcinoma developed obstructive uropathy from CSCC with bladder trigone invasion and adrenal metastasis.

  • 3

    Initial workup revealed acute kidney injury and severe urinary tract infection, leading to emergency interventions including ureteral stenting.

  • 4

    Pathological confirmation of bladder invasion was achieved through biopsy, showing invasive squamous cell carcinoma with diffuse p16 positivity.

  • 5

    The patient underwent palliative urinary diversion, which provided temporary relief, but she died two months after diagnosis due to disease progression.

Original Source(s)

HPV-associated moderately differentiated squamous cell carcinoma of the cervix with pathologically confirmed bladder invasion and radiologically presumed adrenal metastasis in a patient with prior lung adenocarcinoma resection: a rare case report and clinical discussion

  • by Yaxiong Tang, Yanbo Dai, Min Jing, Kang Wang

  • July 10, 2026

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