Dorsolateral Prefrontal rTMS Symptom Cluster Response Trajectories for Depression - Takeaways - MDSpire
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Response Patterns of Depression Symptoms Following Dorsolateral Prefrontal rTMS Treatment

  • By

  • Tyler S. Kaster

  • Xiao Chen

  • Jonathan Downar

  • Fidel Vila-Rodriguez

  • Danielle A. Baribeau

  • Kevin E. Thorpe

  • Zafiris J. Daskalakis

  • Chao-Gan Yan

  • Daniel M. Blumberger

  • September 24, 2026

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  • 1

    Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for individuals with treatment-resistant depression (TRD).

  • 2

    Remission rates for TRD patients receiving rTMS range from 20% to 40%, with many individuals experiencing insufficient benefit from the treatment.

  • 3

    Depression's heterogeneity presents challenges for personalized rTMS treatment strategies, as it encompasses over 200 symptom combinations.

  • 4

    The study utilized group-based multitrajectory modeling to identify distinct symptom-cluster response trajectories in TRD patients undergoing rTMS.

  • 5

    Data for this cohort study were derived from the THREE-D trial, which compared different rTMS stimulation protocols in major depressive disorder.

Original Source(s)

Dorsolateral Prefrontal rTMS Symptom Cluster Response Trajectories for Depression

  • by Tyler S. Kaster, Xiao Chen, Jonathan Downar, Fidel Vila-Rodriguez, Danielle A. Baribeau, Kevin E. Thorpe, Zafiris J. Daskalakis, Chao-Gan Yan, Daniel M. Blumberger

  • September 24, 2026

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