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1
Severe pneumonia in children is a leading cause of hospitalization and infection-related mortality, influenced by both pathogens and host immune responses.
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2
CD4+ T cells play a crucial role in coordinating immune responses, but their function may be impaired in severe pneumonia, affecting disease outcomes.
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3
Tim-3 is an immune regulator that can indicate various states of CD4+ T-cell function, reflecting activation or dysfunction depending on the disease context.
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4
Cytokines like IL-6, IL-8, and TNF-α contribute to inflammation and systemic injury in severe pneumonia, amplifying immune dysregulation.
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5
Current studies often lack integration of adaptive immune status with inflammatory markers, leaving gaps in understanding the immunopathogenesis of severe pneumonia.
