Underlying Causes and Preventability of Hospital-Onset Sepsis Events - Takeaways - MDSpire
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Identifying Root Causes and Mitigation Strategies for Sepsis Occurring in Hospitals

  • By

  • Fizza Manzoor

  • Michael Klompas

  • Saranya Seetharaman

  • Christina Chan

  • Chanu Rhee

  • September 17, 2026

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  • 1

    Hospital-onset sepsis occurred in 5212 of 558,037 admissions, representing 0.9% of total admissions in the studied cohort.

  • 2

    Infections accounted for 79% of hospital-onset sepsis events, with respiratory infections being the most frequent at 56%.

  • 3

    Approximately 31% of infection-related hospital-onset sepsis cases were classified as potentially preventable based on detailed record reviews.

  • 4

    Key opportunities for preventing sepsis included improving infection management and implementing strategies to prevent nonventilator hospital-acquired pneumonia.

  • 5

    Noninfectious conditions accounted for 21% of hospital-onset sepsis events, indicating a need for broader surveillance beyond traditional infection metrics.

Original Source(s)

Underlying Causes and Preventability of Hospital-Onset Sepsis Events

  • by Fizza Manzoor, Michael Klompas, Saranya Seetharaman, Christina Chan, Chanu Rhee

  • September 17, 2026

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