Efficacy of Upadacitinib in Managing Coexisting Psoriasis and Lichen Planus: A Case Study - Takeaways - MDSpire

Efficacy of Upadacitinib in Managing Coexisting Psoriasis and Lichen Planus: A Case Study

  • By

  • Xingmo Li

  • Jinxu Qi

  • Liping Shi

  • Lijuan Liu

  • Xiaoyu Xie

  • Guoqiang Zhang

  • Qing Zhu

  • April 20, 2026

  • 0 min

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  • 1

    The article presents a rare case of coexisting psoriasis and lichen planus in a female patient, highlighting treatment challenges.

  • 2

    Initial treatments with acitretin and topical mometasone were ineffective due to safety concerns, leading to treatment discontinuation.

  • 3

    Upadacitinib, a selective JAK-1 inhibitor, was initiated and resulted in significant improvement within three months.

  • 4

    The case underscores the complex interplay between psoriasis and lichen planus, suggesting immune dysregulation as a potential mechanism.

  • 5

    This report aims to enhance clinical decision-making regarding the management of psoriasis comorbidities.

Original Source(s)

Efficacy of Upadacitinib in Managing Coexisting Psoriasis and Lichen Planus: A Case Study

  • by Xingmo Li, Jinxu Qi, Liping Shi, Lijuan Liu, Xiaoyu Xie, Guoqiang Zhang, Qing Zhu

  • April 20, 2026

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