Polysaccharide from Laminaria japonica Alleviates Acute Neuroinflammation in Cerebral Ischemia-Reperfusion Injury via Csf3-Related Mechanisms

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Laminaria japonica polysaccharide (LJP) exhibits neuroprotective effects in cerebral ischemia/reperfusion injury by modulating neuroinflammation.
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LJP administration significantly reduced infarct volume and improved neurological function in a mouse model of transient middle cerebral artery occlusion.
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The structural analysis of LJP revealed it is enriched in fucose, galacturonic acid, glucuronic acid, and sulfate groups.
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Csf3 was identified as a key mediator in LJP's mechanism, with its suppression linked to reduced microglial pro-inflammatory polarization.
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These findings suggest LJP as a promising phytotherapeutic agent for ischemic stroke, targeting Csf3-related neuroinflammatory pathways.

Frontiers In Immunology

by Tangming Guan, Siyu Chen, Dongbo Jiang, Weiming Cai, Huayan Chen, Yan Wang, Kefeng Wu, Xin Zhou
April 23, 2026

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