Dose-dependent tuning of HSP70–Beclin-1 by kaempferol governs autophagy and chemosensitivity - Takeaways - MDSpire

Dose-dependent tuning of HSP70–Beclin-1 by kaempferol governs autophagy and chemosensitivity

  • By

  • Suqin Hu

  • Yanan Guo

  • Mingyan Li

  • Fangli Jin

  • Lei Luo

  • Zhihuan Yan

  • Jing Wang

  • Bao Liu

  • Qinsheng Zhang

  • Wenzhao Luo

  • May 20, 2026

  • 0 min

Share

  • 1

    Kaempferol modulates the HSP70–Beclin-1 interaction in a dose-dependent manner, influencing autophagy and chemotherapy response.

  • 2

    Low-dose kaempferol stabilizes the HSP70–Beclin-1 complex, suppressing autophagic flux and reducing chemotherapy-induced apoptosis.

  • 3

    High-dose kaempferol disrupts the HSP70–Beclin-1 complex, enhances autophagic flux, and activates AMPK/mTOR and ER stress–JNK signaling.

  • 4

    In vivo, high-dose kaempferol enhances cisplatin's antitumor activity, while low-dose kaempferol diminishes it.

  • 5

    The study reveals a molecular framework for optimizing natural product dosing to leverage autophagy-based chemosensitization in cancer.

Original Source(s)

Dose-dependent tuning of HSP70–Beclin-1 by kaempferol governs autophagy and chemosensitivity

  • by Suqin Hu, Yanan Guo, Mingyan Li, Fangli Jin, Lei Luo, Zhihuan Yan, Jing Wang, Bao Liu, Qinsheng Zhang, Wenzhao Luo

  • May 20, 2026

Related Content

Efficacy and Safety of Immunotherapy in Head and Neck Tumors: A Systematic Review and Meta-Analysis of Clinical Outcomes and Survival Benefits

Matrix metalloproteinase expression in basal cell carcinoma, squamous carcinoma, and melanoma: diagnostic and prognostic potential

Anti-PD-1 monoclonal antibody combined with chemotherapy for porocarcinoma: a case report and literature review