Establishment and internal-external validation of a 28-day mortality prediction model for septic shock patients with left ventricular systolic dysfunction - Takeaways - MDSpire

Establishment and internal-external validation of a 28-day mortality prediction model for septic shock patients with left ventricular systolic dysfunction

  • By

  • Jia Lin

  • Xiaojia Wang

  • Kai Chen

  • Yafang Liu

  • Yizhuo Zhang

  • Tianmiao Xu

  • Xiaojuan Yang

  • June 30, 2026

  • 0 min

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  • 1

    The study developed a 28-day mortality prediction model for septic shock patients with left ventricular systolic dysfunction (LVSD) as a key risk factor.

  • 2

    Independent predictors of 28-day mortality included LVSD, decreased pH, atrial arrhythmia, dopamine use, and reduced PaO2/FiO2.

  • 3

    The model demonstrated an area under the ROC curve (AUC) of 0.767 in the training cohort and 0.779 after internal validation.

  • 4

    External validation confirmed the model's reliability, showing superior predictive performance compared to the APACHE II score.

  • 5

    A web-based dynamic nomogram calculator for the mortality prediction model is available for free public use.

Original Source(s)

Establishment and internal-external validation of a 28-day mortality prediction model for septic shock patients with left ventricular systolic dysfunction

  • by Jia Lin, Xiaojia Wang, Kai Chen, Yafang Liu, Yizhuo Zhang, Tianmiao Xu, Xiaojuan Yang

  • June 30, 2026

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