Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure

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Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, life-threatening condition characterized by widespread keratinocyte necrosis.
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An extremely preterm infant developed SJS/TEN overlap with mucosal involvement after receiving multiple courses of broad-spectrum antibiotics.
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Diagnosis of SJS/TEN in neonates is challenging due to the presence of common mimickers in the neonatal intensive care unit.
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The infant's skin biopsy confirmed full-thickness keratinocyte necrosis, and he later died from septic shock and multi-organ failure.
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Management of SJS/TEN in neonates includes prompt withdrawal of suspected drugs and multidisciplinary supportive care.

Frontiers In Medicine

by Adnan Hadid, Lana A. Shaiba, Mona Alkallabi, Khalid Nabil Nagshabandi, Nora Al-Saud, Rodhan Khaled Alnahdi, Layan Alsanad, Maee Barakeh, Naif Ahmed Alshehri, Khalid Faisal Alkahtani, Adel Abdulaziz Alsuhaibani, Abdulmalik Abdulaziz Alharbi
June 22, 2026

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