Systemic regulation of rheumatoid arthritis by mesenchymal stem cells: from immune homeostasis to microbiota modulation - Takeaways - MDSpire

Systemic regulation of rheumatoid arthritis by mesenchymal stem cells: from immune homeostasis to microbiota modulation

  • By

  • Liujiayu Li

  • Jieling Wu

  • Yutong Wu

  • Juan Liu

  • Lu Feng

  • Shangfu Xu

  • Yuying Wang

  • Limei Yu

  • July 14, 2026

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  • 1

    Rheumatoid arthritis (RA) is an autoimmune disease causing chronic synovitis and joint destruction, with a global prevalence of 0.5%-1.0%.

  • 2

    Mesenchymal stem cells (MSCs) show promise in RA treatment due to their immunomodulatory and regenerative properties.

  • 3

    MSCs exert local effects by modulating immune cell balance and suppressing osteoclast activity, aiding joint repair.

  • 4

    The review highlights a novel 'gut-MSC-immune' axis, suggesting MSCs may influence systemic immune homeostasis.

  • 5

    Future research should focus on standardizing MSC protocols and validating their long-term efficacy in large-scale trials.

Original Source(s)

Systemic regulation of rheumatoid arthritis by mesenchymal stem cells: from immune homeostasis to microbiota modulation

  • by Liujiayu Li, Jieling Wu, Yutong Wu, Juan Liu, Lu Feng, Shangfu Xu, Yuying Wang, Limei Yu

  • July 14, 2026

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