Prognostic significance of extracapsular extension in patients with non-small cell lung cancer following neoadjuvant chemoimmunotherapy: a retrospective cohort study - Takeaways - MDSpire

Prognostic significance of extracapsular extension in patients with non-small cell lung cancer following neoadjuvant chemoimmunotherapy: a retrospective cohort study

  • By

  • Jianing Qiu

  • Shaoling Li

  • Linfeng Ge

  • Suyu Wang

  • Xinlei Hou

  • Xinyu Ling

  • July 15, 2026

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  • 1

    Extracapsular extension (ECE) is associated with worse disease-free survival (DFS) in non-small cell lung cancer (NSCLC) patients after neoadjuvant chemoimmunotherapy (NCIT).

  • 2

    In multivariable analysis, ECE was identified as an independent prognostic factor for DFS, with a hazard ratio of 2.37 (95% CI: 1.28–4.41, P = 0.006).

  • 3

    Integrating ECE status with major pathologic response (MPR) improved predictive accuracy for 2-year DFS, increasing the area under the curve from 0.591 to 0.706.

  • 4

    Lymphovascular invasion (LVI) was found to be an independent predictor of overall survival (OS) in this cohort, with a hazard ratio of 3.99 (95% CI: 1.59–10.02, P = 0.003).

  • 5

    The study highlights the need for intensified postoperative surveillance in ECE-positive NSCLC patients to facilitate early detection and management of recurrence.

Original Source(s)

Prognostic significance of extracapsular extension in patients with non-small cell lung cancer following neoadjuvant chemoimmunotherapy: a retrospective cohort study

  • by Jianing Qiu, Shaoling Li, Linfeng Ge, Suyu Wang, Xinlei Hou, Xinyu Ling

  • July 15, 2026

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