Management of locally advanced lynch syndrome rectal cancer during pregnancy with neoadjuvant immunochemotherapy: a case report

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Lynch syndrome is a hereditary cancer predisposition syndrome that complicates the diagnosis and treatment of colorectal cancer during pregnancy.
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A 37-year-old pregnant woman with LS was diagnosed with locally advanced rectal cancer, leading to a medical termination of pregnancy for treatment considerations.
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The patient underwent neoadjuvant chemoradiotherapy and immunotherapy, achieving significant tumor regression before surgical intervention.
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Postoperative adjuvant therapy was completed without severe adverse events, and the patient remained disease-free at 24 months follow-up.
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Multidisciplinary management is crucial for LS-associated rectal cancer during pregnancy to optimize maternal outcomes while minimizing risks.

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