A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range - Takeaways - MDSpire

A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range

  • By

  • Run Zhao

  • Linlin Che

  • Xiao Li

  • Xiaofang Li

  • Qianyan Song

  • June 30, 2026

  • 0 min

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  • 1

    The study analyzed 1854 IVF patients to evaluate the impact of gonadotropin dosage on embryo quality and pregnancy outcomes.

  • 2

    Group 1, with a Gn dose ≤1,550 IU, showed significantly higher rates of excellent embryos and live births compared to higher dosage groups.

  • 3

    Regression analysis indicated that total Gn was an independent risk factor for positive HCG rates, abortion, and live births.

  • 4

    Increases in Gn above specific thresholds resulted in decreased rates of blastocyst formation, positive HCG, and live births.

  • 5

    The findings suggest that adjusting Gn dosage may improve IVF outcomes by optimizing embryo quality and pregnancy success.

Original Source(s)

A retrospective cohort study on the impact of gonadotropin dose on embryo quality and pregnancy outcome: identification of optimal dose range

  • by Run Zhao, Linlin Che, Xiao Li, Xiaofang Li, Qianyan Song

  • June 30, 2026

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