Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus - Takeaways - MDSpire
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Effects of Prolonged High Disease Activity on Damage Accumulation and Clinical Outcomes in Pediatric Systemic Lupus Erythematosus

  • By

  • Ninlapat Jidmahawong

  • Butsabong Lerkvaleekul

  • Kwanchai Pirojsakul

  • Soamarat Vilaiyuk

  • June 18, 2026

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  • 1

    The study assessed the impact of cumulative high disease activity on damage accrual in childhood-onset systemic lupus erythematosus (cSLE).

  • 2

    Among 196 cSLE patients, 64.3% experienced high disease activity status (HDAS), which was linked to a higher rate of damage accrual.

  • 3

    Patients with time-adjusted cumulative HDAS (cHDAS) ≥5% had a significantly shorter mean time to damage compared to those with cHDAS <5%.

  • 4

    Neuropsychiatric involvement and cHDAS ≥5% were identified as independent predictors of damage accrual in cSLE patients.

  • 5

    Increasing thresholds of time-adjusted cHDAS were associated with progressively higher risks of damage accrual in cSLE patients.

Original Source(s)

Impact of high disease activity on damage accrual and disease outcomes in childhood-onset systemic lupus erythematosus

  • by Ninlapat Jidmahawong, Butsabong Lerkvaleekul, Kwanchai Pirojsakul, Soamarat Vilaiyuk

  • June 18, 2026

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