Clinical efficacy and safety of ultrasound-guided injection with low-molecular-weight peptides from hydrolyzed collagen in patients with first carpometacarpal joint osteoarthritis - Takeaways - MDSpire

Efficacy and Safety of Ultrasound-Guided Intra-Articular Injection of Low-Molecular-Weight Peptides from Hydrolyzed Collagen in Patients with Osteoarthritis of the First Carpometacarpal Joint

  • By

  • Marin Petric

  • Marco Di Carlo

  • Luca Latini

  • Riccardo Mashadi Mirza

  • Francesco Porta

  • Florentin Ananu Vreju

  • Emilio Filippucci

  • July 20, 2026

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  • 1

    First carpometacarpal joint osteoarthritis is a common condition that leads to pain and functional limitations in daily activities.

  • 2

    The study aims to evaluate the efficacy and safety of ultrasound-guided intra-articular injections of low-molecular-weight peptides in symptomatic CMC-1 OA patients.

  • 3

    Primary endpoints include pain reduction during activity after 3 months, with secondary outcomes assessing various aspects of hand function and pain.

  • 4

    Current injectable treatments for CMC-1 OA include corticosteroids and hyaluronic acid, but their efficacy varies across studies.

  • 5

    Ultrasound guidance may enhance injection accuracy and improve outcomes by allowing real-time imaging of joint structures and inflammation.

Original Source(s)

Clinical efficacy and safety of ultrasound-guided injection with low-molecular-weight peptides from hydrolyzed collagen in patients with first carpometacarpal joint osteoarthritis

  • by Marin Petric, Marco Di Carlo, Luca Latini, Riccardo Mashadi Mirza, Francesco Porta, Florentin Ananu Vreju, Emilio Filippucci

  • July 20, 2026

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