Frequent oropharyngeal detection of Treponema pallidum DNA in patients with syphilis: a cross-sectional study of three anatomical sampling sites - Takeaways - MDSpire
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Prevalent Detection of Treponema pallidum DNA in the Oropharynx of Syphilis Patients: A Cross-Sectional Analysis Across Three Anatomical Sampling Locations

  • By

  • Damian Kadylak

  • Justyna Czarny-Kamm

  • Maciej Pastuszczak

  • Małgorzata Sokołowska-Wojdyło

  • September 21, 2026

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  • 1

    In 2023, 41,051 syphilis cases were confirmed across 29 European Union and European Economic Area countries, a 13% increase from 2022.

  • 2

    The study compared Treponema pallidum (TP) PCR positivity across oropharyngeal, anorectal, and urogenital samples from patients with serologically confirmed syphilis.

  • 3

    Researchers assessed associations with syphilis stage and VDRL titer. Analyses of reinfection and concurrent sexually transmitted infections were exploratory.

  • 4

    Patients were offered sampling at all three anatomical sites, with consent required for each site. Not all patients provided samples from every site.

  • 5

    The EUROArray STI-11 multiplex PCR assay targeted the TP47 gene. Its manufacturer-reported detection limit was 50 DNA copies per PCR reaction.

Original Source(s)

Frequent oropharyngeal detection of Treponema pallidum DNA in patients with syphilis: a cross-sectional study of three anatomical sampling sites

  • by Damian Kadylak, Justyna Czarny-Kamm, Maciej Pastuszczak, Małgorzata Sokołowska-Wojdyło

  • September 21, 2026

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