Utilization of the Seraph® 100 Affinity Blood Filter in a Pediatric Case of Refractory Streptococcal Septic Shock: A Case Study

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Septic shock in pediatrics is a significant cause of morbidity and mortality, especially in refractory cases unresponsive to standard therapy.
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The Seraph® 100 Microbind® affinity blood filter was used in a 7-year-old girl with refractory septic shock caused by invasive Streptococcus pyogenes.
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Hemoperfusion with the Seraph® 100 filter led to improved hemodynamic stability and metabolic parameters within 24–48 hours post-treatment.
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Despite stabilization, the patient suffered severe peripheral ischemia, resulting in bilateral lower-limb amputations but ultimately survived.
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The case suggests potential for hemoperfusion as an adjunctive therapy in pediatric septic shock, warranting further prospective studies.

Frontiers In Pediatrics

by Raul Montero-Yeboles, Laura Maria Saez-García, Esther Ulloa-Santamaria, Ana Diaz-Vico, Maria Jose Lorenzo-Montero, Beatriz Ruiz-Saez
April 17, 2026

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