Baseline serum matrix metalloproteinase-8 and 28-day mortality in sepsis at ICU admission - Takeaways - MDSpire

Baseline serum matrix metalloproteinase-8 and 28-day mortality in sepsis at ICU admission

  • By

  • Huanqin Liu

  • Yingkui Song

  • Yanan Lv

  • Feng Qu

  • Jikui Shi

  • January 31, 2026

  • 0 min

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  • 1

    Matrix metalloproteinase-8 (MMP-8) levels at ICU admission are associated with 28-day mortality in sepsis patients.

  • 2

    Higher baseline MMP-8 levels correlate with increased mortality, with an adjusted hazard ratio of 1.34 per 10 ng/mL.

  • 3

    Patients in the highest MMP-8 tertile have significantly higher mortality rates compared to those in the lowest tertile.

  • 4

    MMP-8 serves as a marker of inflammatory injury and may reflect excessive neutrophil activation in sepsis.

  • 5

    The addition of MMP-8 improves mortality prediction beyond established clinical models, warranting further validation.

Original Source(s)

Baseline serum matrix metalloproteinase-8 and 28-day mortality in sepsis at ICU admission

  • by Huanqin Liu, Yingkui Song, Yanan Lv, Feng Qu, Jikui Shi

  • January 31, 2026

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