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The Relationship Between Anemia and Blood Biomarkers in the Progression of Alzheimer’s Disease in Dementia

  • By

  • Martina Valletta

  • Davide Liborio Vetrano

  • Chengxuan Qiu

  • Marco Canevelli

  • Edoardo Miccoli

  • Sarah Andersson

  • Claudia Fredolini

  • Giuseppe Bruno

  • Bengt Winblad

  • Laura Fratiglioni

  • Giulia Grande

  • April 17, 2026

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  • 1

    Anemia affects approximately 10% of individuals aged 65 and older in the US, with prevalence increasing with age.

  • 2

    Anemia is associated with increased dementia risk, potentially due to chronic cerebral hypoxia and oxidative stress.

  • 3

    Blood biomarkers like p-tau217, NfL, and GFAP correlate with Alzheimer's disease pathology and may indicate early neurodegeneration.

  • 4

    The study utilized data from over 2000 older adults to examine the relationship between hemoglobin levels and dementia risk.

  • 5

    Cox proportional hazards regression models were used to analyze the association of baseline hemoglobin levels with incident dementia.

Original Source(s)

Anemia and Blood Biomarkers of Alzheimer Disease in Dementia Development

  • by Martina Valletta, Davide Liborio Vetrano, Chengxuan Qiu, Marco Canevelli, Edoardo Miccoli, Sarah Andersson, Claudia Fredolini, Giuseppe Bruno, Bengt Winblad, Laura Fratiglioni, Giulia Grande

  • April 17, 2026

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