Long-range allosteric communication within antibodies affects antigen-binding affinity

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Antibodies play a crucial role in the immune system, with various classes and subclasses differing in structure and function.
2

Allosteric communication within antibodies affects antigen-binding affinities, particularly influenced by antibody class and subclass.
3

Long-range allosteric effects from the Fc region to the Fab region significantly enhance binding affinities compared to Fab-only counterparts.
4

Thermodynamic analysis indicates that differences in antibody flexibility and pre-organization drive the observed allosteric effects.
5

The study provides insights into the allosteric modulation of antibody function, which is important for therapeutic antibody engineering.

Frontiers In Immunology

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