A sequential strategy of upfront radiofrequency ablation followed by endoscopic papillectomy for complex ampullary tumors

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Endoscopic papillectomy (EP) is the first-line treatment for ampullary tumors, while radiofrequency ablation (RFA) serves as an alternative or adjunctive treatment.
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A study of 132 patients showed a technical success rate of 100% for EP, with a short-term clinical success rate of 96.6%.
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Adverse events occurred in 20.5% of patients, with tumor size identified as a significant risk factor for complications.
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The short-term clinical success rate for the RFA group was 91.7%, with adverse events observed in 16.7% of patients.
5

The study suggests that an upfront RFA strategy followed by EP may reduce adverse events in select patients with complex ampullary tumors.

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