Comparative Analysis of PGT-A and Expectant Management in Fertile Individuals Experiencing Recurrent Pregnancy Loss and Previous Aneuploidy: A Five-Year Dual-Center Study on Cumulative Pregnancy Outcomes

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The study compared preimplantation genetic testing for aneuploidy (PGT-A) and expectant management (EM) in fertile patients with recurrent pregnancy loss.
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Among 216 patients, 145 underwent PGT-A and 71 chose EM, with primary outcomes focusing on live-birth achievement within 12 months.
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Results showed lower conception leading to live birth rates within 12 months for PGT-A compared to EM (52.1% vs 81.7%; P < 0.001).
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Five-year cumulative live birth rates were comparable between PGT-A and EM (94.4% vs 87.3%; P = 0.15), but PGT-A had a longer time to pregnancy.
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Incremental cost-effectiveness ratios for PGT-A were ¥1,203,800 per additional live birth and ¥1,504,800 per miscarriage prevented.

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