Bundled Care Strategy May Reduce Moderate to Severe AKI - Takeaways - MDSpire

Bundled Care Strategy May Reduce Moderate to Severe AKI

Multicenter trial finds KDIGO-recommended approach lowers moderate to severe acute kidney injury; measured 90-day outcomes were similar between groups

  • By

  • Kathryn Wighton

  • April 17, 2026

  • 5 min

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  • 1

    A preventive care strategy based on KDIGO recommendations reduced moderate to severe AKI after major surgery in the BigpAK-2 trial.

  • 2

    Moderate to severe AKI occurred in 14% of the intervention group versus 22% in the control group, indicating a significant reduction.

  • 3

    The preventive strategy included hemodynamic optimization and avoidance of nephrotoxic drugs, targeting specific clinical parameters.

  • 4

    Implementation of the full preventive strategy was achieved in 47% of patients, increasing to 63% when strict glycemic control was excluded.

  • 5

    The trial's findings suggest that supportive care can effectively reduce AKI risk in high-risk surgical patients, though broader adoption may be limited.

Original Source(s)

Bundled Care Strategy May Reduce Moderate to Severe AKI

  • by Kathryn Wighton

  • April 17, 2026

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