A novel lesion severity index to predict 90-day postoperative survival in brain metastasis patients

1

A novel Metastatic Brain Lesion Score (MBLS) was developed to predict 90-day postoperative mortality in patients undergoing craniotomy for brain metastases.
2

The study analyzed 548 patients in a creation cohort and 318 patients in a validation cohort to assess the effectiveness of the MBLS.
3

Significant predictors of 90-day mortality included age, functional status, chronic pain medication use, and specific tumor characteristics.
4

The MBLS was compared to existing surgical risk scores, demonstrating its potential for improved risk estimation in brain metastasis surgeries.
5

The study highlights the complexity of assessing surgical risk in brain metastasis patients due to unique cancer-related factors.

Journal Of Neuro-Oncology

by Daniel C. Kreatsoulas, Joanne Kim, Mark Damante, Anna Orr, Joshua Wang, Joshua Vignolles-Jeong, Maxwell Gruber, Varun Shah, Nicholas Musgrave, Russell Lonser, Daniel Prevedello, J. Bradley Elder, Douglas A. Hardesty
June 11, 2025

1