The Development of Clinical Trials for CNS Tumors by RTOG and NRG Oncology

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RTOG/NRG trials have significantly influenced evidence-based care for CNS tumors, addressing unique challenges like biological heterogeneity and infiltrative growth.
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The RTOG Brain Tumor Committee was established in the 1970s to assess innovative approaches for CNS tumors, focusing on radiotherapy and chemotherapy.
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Long-term follow-up from RTOG 94-02 demonstrated that molecular stratification can inform treatment benefits in neuro-oncology, impacting trial eligibility.
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NRG Oncology collaborates with other National Clinical Trials Network groups to enhance trial development and patient enrollment, accelerating evidence generation.
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Trials have evolved to integrate advanced imaging and cognitive-function preservation strategies, reflecting the maturation of cooperative group science.

Journal Of Neuro-Oncology

by Kavita Sehrawat, Mei-Yin C. Polley, Michael A. Vogelbaum, Mark Gilbert, Arnab Chakravarti, Daniel P. Cahill, Andrew B. Lassman, David R. Raleigh, Erik P. Sulman, Mitch Machtay, Quynh Thu Le, Walter Curran, Vinai Gondi, Minesh P. Mehta
September 15, 2026

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