Trajectories of symptom scores and risk of cardiovascular events in the vulnerable phase of heart failure: an analysis using a latent class trajectory model - Takeaways - MDSpire

Symptom Score Patterns and Cardiovascular Event Risk During the Vulnerable Phase Post-Heart Failure Discharge: Insights from a Latent Class Trajectory Analysis

  • By

  • Dan Xiao

  • Yuan Xu

  • Yan Jiang

  • Zhiteng Xiong

  • Qihui Shen

  • Xinglan Sun

  • Xiaoyun Xiong

  • Bing Hu

  • July 20, 2026

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  • 1

    The study analyzed symptom trajectories in 1,109 chronic heart failure patients during the vulnerable phase post-discharge.

  • 2

    Four distinct symptom trajectory groups were identified: persistently declining, slowly improving, stable-moderate, and stable-high.

  • 3

    Patients in the persistently declining group had significantly higher odds of major adverse cardiovascular events compared to the stable-moderate group.

  • 4

    The exploratory mediation analysis indicated a significant indirect association between symptom trajectories and cardiovascular outcomes.

  • 5

    Tracking symptom trajectories using the KCCQ may enhance early risk stratification and management for heart failure patients post-discharge.

Original Source(s)

Trajectories of symptom scores and risk of cardiovascular events in the vulnerable phase of heart failure: an analysis using a latent class trajectory model

  • by Dan Xiao, Yuan Xu, Yan Jiang, Zhiteng Xiong, Qihui Shen, Xinglan Sun, Xiaoyun Xiong, Bing Hu

  • July 20, 2026

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