Prevalence and Risk Factors of Liver Fibrosis Among People With HIV and Metabolic Dysfunction–Associated Steatotic Liver Disease

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The study assessed liver fibrosis prevalence and risk factors in individuals with HIV and metabolic dysfunction-associated steatotic liver disease (MASLD).
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Among 361 participants, 39.06% were diagnosed with MASLD, with significant fibrosis found in 121 individuals, highlighting a high prevalence of liver issues.
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Independent risk factors for significant liver fibrosis included elevated alanine aminotransferase levels and type 2 diabetes among those with MASLD.
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For lean MASLD patients, significant fibrosis risk factors included elevated aspartate aminotransferase levels and the use of non-nucleoside reverse transcriptase inhibitors.
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The findings emphasize the need for early identification and management of liver fibrosis in people with HIV to reduce morbidity and mortality.

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