Correlation of Shock-Lactate Index with 28-Day Mortality in Patients Experiencing Sepsis-Related AKI: An Analysis Using the MIMIC-IV Database - Takeaways - MDSpire

Correlation of Shock-Lactate Index with 28-Day Mortality in Patients Experiencing Sepsis-Related AKI: An Analysis Using the MIMIC-IV Database

  • By

  • Dezhi Ren

  • Shuai Wang

  • Siyao Xu

  • Hui Wang

  • Shanshan Zhai

  • Yue Qiu

  • Zeliang Qiu

  • Jun Duan

  • February 20, 2026

  • 0 min

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  • 1

    Sepsis is a critical condition with high mortality, particularly when associated with acute kidney injury (AKI), affecting up to 60% of sepsis patients.

  • 2

    The Shock-Lactate Index (SLI) combines heart rate, blood pressure, and lactate levels to enhance early detection of shock and predict mortality in sepsis-related AKI.

  • 3

    Lactate levels serve as a significant prognostic marker in sepsis, indicating tissue hypoperfusion and correlating with increased mortality risk.

  • 4

    The study utilized the MIMIC-IV database to analyze the predictive value of SLI for 28-day mortality in patients with sepsis-associated renal injury.

  • 5

    Combining shock index and lactate levels improves risk stratification and clinical decision-making for patients experiencing sepsis-related AKI.

Original Source(s)

Correlation of Shock-Lactate Index with 28-Day Mortality in Patients Experiencing Sepsis-Related AKI: An Analysis Using the MIMIC-IV Database

  • by Dezhi Ren, Shuai Wang, Siyao Xu, Hui Wang, Shanshan Zhai, Yue Qiu, Zeliang Qiu, Jun Duan

  • February 20, 2026

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