Clinical characteristics and predictors of adverse outcomes in children with acute rheumatic fever from a high-endemic region of Brazil - Takeaways - MDSpire

Clinical characteristics and predictors of adverse outcomes in children with acute rheumatic fever from a high-endemic region of Brazil

  • By

  • Renata Fonseca Mendoza

  • Letícia Leão de Oliveira

  • Bernardo Fonseca Mendoza

  • Jose Luiz Padilha da Silva

  • Paulo Henrique M. Melo

  • José Augusto Almeida Barbosa

  • Géssica Silva Santana

  • Airandes Pinto

  • Ndate Fall

  • Andrea Beaton

  • Maria Carmo Pereira Nunes

  • June 10, 2026

  • 0 min

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  • 1

    Acute rheumatic fever (ARF) is a significant cause of pediatric cardiovascular morbidity and rheumatic heart disease in low- and middle-income countries.

  • 2

    In a study of 151 children with ARF in Brazil, 76% had carditis, with 49% experiencing moderate-to-severe involvement, primarily affecting the mitral valve.

  • 3

    The study identified independent predictors of adverse outcomes, including absence of fever, higher ESR, and lower hematocrit.

  • 4

    Erythrocyte sedimentation rate (ESR) improved risk prediction for severe outcomes, demonstrating good model discrimination with a C-statistic of 0.82.

  • 5

    Simple inflammatory and hematologic markers can aid in risk stratification for ARF, potentially reducing progression to advanced rheumatic heart disease.

Original Source(s)

Clinical characteristics and predictors of adverse outcomes in children with acute rheumatic fever from a high-endemic region of Brazil

  • by Renata Fonseca Mendoza, Letícia Leão de Oliveira, Bernardo Fonseca Mendoza, Jose Luiz Padilha da Silva, Paulo Henrique M. Melo, José Augusto Almeida Barbosa, Géssica Silva Santana, Airandes Pinto, Ndate Fall, Andrea Beaton, Maria Carmo Pereira Nunes

  • June 10, 2026

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