Analysis of Demographics, Clinicopathological Features, and Treatment Approaches for Oral Squamous Cell Carcinoma Patients at a Johannesburg Academic Hospital: A Five-Year Retrospective Study - Takeaways - MDSpire

Analysis of Demographics, Clinicopathological Features, and Treatment Approaches for Oral Squamous Cell Carcinoma Patients at a Johannesburg Academic Hospital: A Five-Year Retrospective Study

  • By

  • Gal Feller

  • Daniel Mmereki

  • Faiza Mahomed

  • Razia AG Khammissa

  • Duvern Ramiah

  • November 22, 2025

  • 0 min

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  • 1

    Oral squamous cell carcinoma (OSCC) accounts for over 90% of malignant oral tumors, with significant prevalence in low- and middle-income countries.

  • 2

    Established risk factors for OSCC include tobacco use, alcohol consumption, and poor oral hygiene, leading to late-stage diagnoses.

  • 3

    At CMJAH, many OSCC patients present with inoperable, late-stage disease, primarily treated with radiotherapy and concurrent chemotherapy.

  • 4

    The study analyzed demographic and clinicopathological features of OSCC patients treated at CMJAH from 2014 to 2019, focusing on treatment outcomes.

  • 5

    Radiotherapy for OSCC at CMJAH is associated with significant acute and chronic toxicities, impacting patient quality of life and treatment adherence.

Original Source(s)

Analysis of Demographics, Clinicopathological Features, and Treatment Approaches for Oral Squamous Cell Carcinoma Patients at a Johannesburg Academic Hospital: A Five-Year Retrospective Study

  • by Gal Feller, Daniel Mmereki, Faiza Mahomed, Razia AG Khammissa, Duvern Ramiah

  • November 22, 2025

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