Agreement between in vivo and ex vivo photon-counting CT measurements of subchondral trabecular bone features in patients with knee osteoarthritis

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Bone changes in osteoarthritis include subchondral sclerosis, cysts, and osteophyte formation, impacting joint health.
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Conventional CT lacks resolution to accurately depict trabecular bone structures, necessitating ex vivo imaging methods.
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Photon-Counting CT (PCCT) offers superior spatial resolution and can produce Ultra-High-Resolution imaging in vivo.
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The study aimed to assess the correlation between in vivo and ex vivo PCCT measurements of subchondral bone in knee OA patients.
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Participants in the study underwent both in vivo PCCT scans and ex vivo scans of tibial plateau biopsies collected during surgery.

European Radiology

by Camilla Toft Nielsen, Mikael Boesen, Marius Henriksen, Janus Uhd Nybing, Sophia Wiinberg Bardenfleth, Christian Kento Rasmussen, Mathias Willadsen Brejnebøl, Asbjørn Seenithamby Poulsen, Saber Muthanna Aljuboori, Kristine Ifigenia Bunyoz, Søren Overgaard, Anders Troelsen, Henning Bliddal, Henrik Gudbergsen, Felix Müller
August 27, 2025

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