Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis - Takeaways - MDSpire

Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis

  • By

  • Ying Wang

  • Shuheng Pan

  • Fengying Zhang

  • Huimin Ma

  • Rihan Wu

  • Jing Zhang

  • Xia Li

  • July 2, 2026

  • 0 min

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  • 1

    Kushen Gel treatment significantly decreased microbial alpha diversity and shifted the vaginal microbiome toward a Lactobacillus-dominant state.

  • 2

    The HR-HPV clearance rate after Kushen Gel treatment was 82.9%, with significant reductions in vaginal pH and Nugent scores.

  • 3

    Pro-inflammatory cytokines IL-8, IL-6, and TNF-α decreased significantly, while anti-viral IFN-γ levels increased after treatment.

  • 4

    A marked reduction in pathobionts such as Gardnerella, Sneathia, and Prevotella was observed post-treatment.

  • 5

    Kushen Gel is associated with a transition from a pro-inflammatory to an anti-viral immune microenvironment in patients.

Original Source(s)

Identification of key vaginal microbial signatures and immune remodeling associated with HR-HPV clearance following Kushen Gel treatment: a longitudinal analysis

  • by Ying Wang, Shuheng Pan, Fengying Zhang, Huimin Ma, Rihan Wu, Jing Zhang, Xia Li

  • July 2, 2026

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