How Metal Imbalance Rewires Metabolism

Integrated metallomics and metabolomics map metabolic responses to metal imbalance

1

The study investigates how metal homeostasis disturbances affect metabolism in Caenorhabditis elegans.
2

Zinc is identified as a central regulator of metal balance, influencing the distribution of iron and manganese.
3

Chronic iron exposure leads to significant shifts in metabolites linked to central carbon metabolism.
4

Neurons may be particularly vulnerable to metabolic strain from disrupted metal homeostasis.
5

The research advocates for combining metal speciation analysis with metabolomics to explore metal dysregulation effects.