The Predictive Value of Albumin-to-Creatinine Ratio on Mortality and Its Mediation in Metabolic Dysfunction-Associated Steatotic Liver Disease Among U.S. Adults: Insights from NHANES 1999–2018 - Takeaways - MDSpire

The Predictive Value of Albumin-to-Creatinine Ratio on Mortality and Its Mediation in Metabolic Dysfunction-Associated Steatotic Liver Disease Among U.S. Adults: Insights from NHANES 1999–2018

  • By

  • Huanjie Zhou

  • Hao Huang

  • Huiliu Zhao

  • Naiqi Pang

  • Meifang Huang

  • Chao Ou

  • Ming Lao

  • November 19, 2025

  • 0 min

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  • 1

    Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to obesity, type 2 diabetes, hypertension, and cardiovascular disease.

  • 2

    The albumin-to-creatinine ratio (ACR) serves as a biomarker for microalbuminuria, indicating systemic metabolic dysfunction and increased mortality risk.

  • 3

    This study utilized NHANES data from 1999 to 2018 to explore ACR's predictive value on mortality in MASLD patients.

  • 4

    ACR may mediate the relationship between diabetes, hypertension, and mortality, highlighting its potential as a therapeutic target.

  • 5

    Understanding ACR's role could enhance risk stratification and clinical management of individuals with high-risk metabolic liver disease.

Original Source(s)

The Predictive Value of Albumin-to-Creatinine Ratio on Mortality and Its Mediation in Metabolic Dysfunction-Associated Steatotic Liver Disease Among U.S. Adults: Insights from NHANES 1999–2018

  • by Huanjie Zhou, Hao Huang, Huiliu Zhao, Naiqi Pang, Meifang Huang, Chao Ou, Ming Lao

  • November 19, 2025

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