Identifying emergency department patients at risk of diagnostic discordance between the presumptive emergency department diagnosis and the adjudicated discharge diagnosis: The independent role of frailty - Takeaways - MDSpire
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Recognizing Emergency Department Patients Prone to Diagnostic Discrepancies Between Initial and Final Discharge Diagnoses: The Distinct Influence of Frailty

  • By

  • Yara M.W. van Knippenberg

  • Konstantin Föhse

  • Charlotte C.M. Schaap

  • Mihai G. Netea

  • Jacobien Hoogerwerf

  • Jaap ten Oever

  • August 15, 2026

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  • 1

    Diagnostic discordance between presumptive ED diagnoses and adjudicated discharge diagnoses has been reported in 8% to 43% of patients with suspected infection.

  • 2

    Frailty, reflecting reduced physiological reserve, was independently associated with diagnostic discordance in ED patients with suspected infection.

  • 3

    Frailty and higher age-adjusted comorbidity burden were independently associated with diagnostic discordance, whereas age alone was not independently associated after adjustment.

  • 4

    The analysis included 646 unique adults presenting to the ED with suspected infection after duplicate presentations were excluded.

  • 5

    Diagnostic discordance was defined as disagreement in either the presence or focus of infection between the presumptive ED diagnosis and the adjudicated discharge diagnosis.

Original Source(s)

Identifying emergency department patients at risk of diagnostic discordance between the presumptive emergency department diagnosis and the adjudicated discharge diagnosis: The independent role of frailty

  • by Yara M.W. van Knippenberg, Konstantin Föhse, Charlotte C.M. Schaap, Mihai G. Netea, Jacobien Hoogerwerf, Jaap ten Oever

  • August 15, 2026

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