Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer’s disease therapy - Takeaways - MDSpire

Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer’s disease therapy

  • By

  • Xizhong Ding

  • Xukai Hu

  • Wanqiang Xue

  • Yingrui An

  • Wei Cheng

  • Shaolong Zhang

  • Anhua Lei

  • Jin Zhang

  • July 14, 2026

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  • 1

    Alzheimer's disease is marked by amyloid-β plaque accumulation and chronic neuroinflammation, leading to neuronal loss and cognitive decline.

  • 2

    Monoclonal antibodies targeting amyloid-β have shown limited efficacy due to insufficient clearance and treatment-associated neuroinflammation.

  • 3

    A novel anti-inflammatory CAR-Microglia was developed, utilizing TAM receptors to enhance Aβ clearance while reducing proinflammatory cytokine release.

  • 4

    AXL-CAR-iMGLs demonstrated improved Aβ clearance in an AD mouse model without severe adverse effects, indicating potential for cell therapy.

  • 5

    The study establishes TAM receptor-based CAR-iMGLs as a promising approach for treating Alzheimer's disease and other neurodegenerative disorders.

Original Source(s)

Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer’s disease therapy

  • by Xizhong Ding, Xukai Hu, Wanqiang Xue, Yingrui An, Wei Cheng, Shaolong Zhang, Anhua Lei, Jin Zhang

  • July 14, 2026

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