Assessment of the effectiveness and safety of anti-VEGF/VEGFR monotherapy versus its combination with immune checkpoint inhibitors in advanced or metastatic renal cell carcinoma: a network meta-analysis - Takeaways - MDSpire

Assessment of the effectiveness and safety of anti-VEGF/VEGFR monotherapy versus its combination with immune checkpoint inhibitors in advanced or metastatic renal cell carcinoma: a network meta-analysis

  • By

  • Min Duan

  • Yanjun Liu

  • Kexin Qiao

  • Zuojing Li

  • Dongsheng Zong

  • January 21, 2026

  • 0 min

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  • 1

    Renal cell carcinoma (RCC) is a prevalent malignancy with a poor prognosis, especially in metastatic cases, necessitating improved treatment strategies.

  • 2

    Targeting the VEGF pathway has become essential in RCC treatment, with anti-VEGF therapies showing improved outcomes over traditional therapies.

  • 3

    Combining immune checkpoint inhibitors with anti-VEGF therapies enhances anticancer activity and survival, despite increased adverse events.

  • 4

    Phase III trials indicate that ICI-based combinations may outperform TKI monotherapy in terms of progression-free and overall survival.

  • 5

    This study aims to compare the efficacy and safety of anti-VEGF monotherapy versus combinations with ICIs in advanced RCC using network meta-analysis.

Original Source(s)

Assessment of the effectiveness and safety of anti-VEGF/VEGFR monotherapy versus its combination with immune checkpoint inhibitors in advanced or metastatic renal cell carcinoma: a network meta-analysis

  • by Min Duan, Yanjun Liu, Kexin Qiao, Zuojing Li, Dongsheng Zong

  • January 21, 2026

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