Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis - Takeaways - MDSpire

Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis

  • By

  • Shanping Shi

  • Wei Song

  • Zhiping Wu

  • Yufeng Cheng

  • Hua Liu

  • Fuju Tian

  • Xiaocui Li

  • May 21, 2026

  • 0 min

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  • 1

    Deep infiltrating endometriosis (DIE) is a severe subtype of endometriosis linked to significant pelvic pain and infertility.

  • 2

    Mendelian randomization revealed causal associations between metabolites, gut microbiota, and immune phenotypes with DIE risk.

  • 3

    A five-gene panel was identified that discriminates between DIE lesions and normal endometrium with high accuracy.

  • 4

    Colocalization analysis identified 324 protein-coding genes, with 42 showing differential expression related to inflammation.

  • 5

    The study supports a gut-immune-pelvic pathway in DIE, highlighting the role of metabolic and immune disturbances.

Original Source(s)

Multi-omics Mendelian randomization integrating metabolism, microbiome and immunity supports a putative gut-immune-pelvic pathway in deep infiltrating endometriosis

  • by Shanping Shi, Wei Song, Zhiping Wu, Yufeng Cheng, Hua Liu, Fuju Tian, Xiaocui Li

  • May 21, 2026

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