Comparing Inflammatory Recovery: Sternal-Sparing Techniques Versus Prolonged Bypass in MICS and Median Sternotomy - A SIRI-Based Study

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The study investigates inflammatory recovery trajectories in minimally invasive cardiac surgery (MICS) versus median sternotomy (MS) using the Systemic Inflammation Response Index (SIRI).
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A total of 235 patients were eligible for analysis, with 89 matched pairs evaluated for changes in SIRI at baseline, postoperative day 1, and day 5.
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On postoperative day 5, the MICS group showed significantly greater inflammatory resolution compared to the MS group, despite longer operative and bypass times.
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ΔSIRI on postoperative day 1 served as a good early-warning biomarker for postoperative pulmonary complications for both surgical approaches.
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The findings suggest that MICS may facilitate faster systemic inflammatory resolution, potentially enhancing recovery compared to conventional sternotomy.

Frontiers In Cardiovascular Medicine

by Chang Wang, Huangwei Li, Qingsong Wu, Linfeng Xie, Jiaming Gao, Liangwan Chen
July 17, 2026

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