The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence - Takeaways - MDSpire

The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence

  • By

  • Feng Cui

  • Yan Chang

  • Xin-Wei Ma

  • Tang-Fen Wang

  • Xin Zhang

  • Tao Hu

  • Qing-Qian Guo

  • Xiao-Yu Feng

  • Xu Guo

  • Tian-Xiao Shen

  • Xiao-Dong Yang

  • Jian Zheng

  • Ke-Jia Hu

  • Jian-Bing Zhu

  • March 25, 2026

  • 0 min

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  • 1

    Sleep disturbances are common in patients undergoing methadone maintenance treatment (MMT) for opioid use disorder (OUD).

  • 2

    The study found increased cortical thickness in specific brain regions of patients with sleep disturbances compared to those without.

  • 3

    Cortical thickness in the left frontalpole cortex correlated positively with sleep quality and daytime dysfunction in MMTS patients.

  • 4

    Findings suggest that sleep disturbances may drive neuroanatomical changes in MMT patients, impacting treatment outcomes.

  • 5

    The study advocates for sleep-targeted interventions to improve treatment efficacy and reduce relapse risk in MMT patients.

Original Source(s)

The effects of sleep disturbances on patients receiving methadone treatment for opioid use disorder: cortical thickness evidence

  • by Feng Cui, Yan Chang, Xin-Wei Ma, Tang-Fen Wang, Xin Zhang, Tao Hu, Qing-Qian Guo, Xiao-Yu Feng, Xu Guo, Tian-Xiao Shen, Xiao-Dong Yang, Jian Zheng, Ke-Jia Hu, Jian-Bing Zhu

  • March 25, 2026

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