Neutrophil-to-lymphocyte ratio and endometriosis: systematic review and meta-analysis - Takeaways - MDSpire
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The Role of Neutrophil-to-Lymphocyte Ratio as a Biomarker in Endometriosis: A Systematic Review and Meta-Analysis

  • By

  • Mattia Dominoni

  • Martina Rita Pano

  • Adalberto Lovotti

  • Virginia Valeria Ferretti

  • Annalisa De Silvestri

  • Barbara Gardella

  • June 22, 2026

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  • 1

    The systematic review analyzed 17 retrospective studies involving 6,679 women, with 3,980 diagnosed with endometriosis.

  • 2

    The neutrophil-to-lymphocyte ratio (NLR) demonstrated a sensitivity of 0.66 and a specificity of 0.63 in diagnosing endometriosis.

  • 3

    The meta-analysis reported a positive likelihood ratio of 1.79 and a negative likelihood ratio of 0.53 for NLR in endometriosis diagnosis.

  • 4

    Endometriosis affects approximately 10% of the population and can lead to chronic pelvic pain and infertility.

  • 5

    The study highlights the contrasting results of NLR and CA 125 as biomarkers for endometriosis diagnosis, suggesting further investigation is needed.

Original Source(s)

Neutrophil-to-lymphocyte ratio and endometriosis: systematic review and meta-analysis

  • by Mattia Dominoni, Martina Rita Pano, Adalberto Lovotti, Virginia Valeria Ferretti, Annalisa De Silvestri, Barbara Gardella

  • June 22, 2026

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