Co-enrolment in critical care trials: a secondary analysis of the RECOVERY-RS trial - Takeaways - MDSpire

Co-enrolment in critical care trials: a secondary analysis of the RECOVERY-RS trial

  • By

  • Christopher Eleftheriou

  • Chen Ji

  • Ranjit Lall

  • Daniel F. McAuley

  • Gavin D. Perkins

  • Keith Couper

  • November 20, 2025

  • 0 min

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  • 1

    Co-enrolment allows patients to participate in multiple clinical studies simultaneously, which can enhance trial delivery in critical care.

  • 2

    In the RECOVERY-RS trial, 62% of participants were co-enrolled in another study, with rates varying from 25% to 97% across hospitals.

  • 3

    Co-enrolled participants were more likely to be male, of white ethnicity, and had fewer co-morbidities compared to non-co-enrolled participants.

  • 4

    Despite differences in patient characteristics, co-enrolment did not significantly affect outcomes such as tracheal intubation or mortality.

  • 5

    The high co-enrolment rate in RECOVERY-RS suggests that unique contexts, like the COVID-19 pandemic, can facilitate successful trial participation.

Original Source(s)

Co-enrolment in critical care trials: a secondary analysis of the RECOVERY-RS trial

  • by Christopher Eleftheriou, Chen Ji, Ranjit Lall, Daniel F. McAuley, Gavin D. Perkins, Keith Couper

  • November 20, 2025

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