The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial - Takeaways - MDSpire

The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial

  • By

  • Lindy Kregting

  • Daan van den Oever

  • Lian Pennings

  • Ruud Pijnappel

  • Nicolien van Ravesteyn

  • Ellen Verschuur

  • Marja van Oirsouw

  • Loes Dunning

  • Hans ‘t Mannetje

  • Ruben van Engen

  • Adriana Bluekens

  • Maartje Smid-Geirnaerdt

  • Cary van Landsveld-Verhoeven

  • Nehmat Houssami

  • Ioannis Sechopoulos

  • Mireille Broeders

  • January 9, 2025

  • 0 min

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  • 1

    The STREAM trial aims to evaluate the effectiveness and cost-effectiveness of digital breast tomosynthesis (DBT) in the Dutch breast cancer screening program.

  • 2

    The trial will compare outcomes between 17,275 participants receiving DBT and 86,400 participants undergoing traditional digital mammography (DM) screening.

  • 3

    Short-term indicators include participation rate, recall rate, detection rate, and positive predictive value of DBT screening.

  • 4

    Medium-term and long-term indicators will assess advanced cancer detection, interval cancer rates, and breast cancer mortality.

  • 5

    The trial is ethically approved and aims to optimize DBT interpretation to ensure feasibility and acceptability among stakeholders.

Original Source(s)

The Screening Tomosynthesis Trial with Advanced Reader Methods (STREAM): design and rationale of a population-based breast cancer screening trial

  • by Lindy Kregting, Daan van den Oever, Lian Pennings, Ruud Pijnappel, Nicolien van Ravesteyn, Ellen Verschuur, Marja van Oirsouw, Loes Dunning, Hans ‘t Mannetje, Ruben van Engen, Adriana Bluekens, Maartje Smid-Geirnaerdt, Cary van Landsveld-Verhoeven, Nehmat Houssami, Ioannis Sechopoulos, Mireille Broeders

  • January 9, 2025

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