Baseline blood eosinophil counts can identify asthma patients who may benefit from shorter steroid courses without early clinical deterioration.
2
An eosinophil-guided approach to corticosteroid duration met noninferiority criteria and reduced cumulative steroid exposure in noneosinophilic exacerbations.
3
Treatment failure rates were similar between eosinophil-guided care (11%) and usual care (7%), meeting the prespecified noninferiority margin.
4
Secondary outcomes, including hospital stay and asthma control scores, showed no significant differences between the eosinophil-guided and usual care groups.
5
The study's limitations include its open-label design, small sample size, and lack of systematic lung function assessments, warranting larger trials.
