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1
The tumor microenvironment significantly influences disease behavior and outcomes in resectable lung cancer beyond tumor-intrinsic features.
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2
Pathological response metrics must adapt to include immune-mediated patterns, necessitating refined criteria for assessing treatment response.
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3
Prognostic assessments should integrate multiple parameters, as combining ypT stage, MPR, and nodal response enhances event-free survival predictions.
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4
The stromal compartment actively drives cancer progression, with cancer-associated fibroblasts contributing to metastasis through extracellular matrix remodeling.
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5
Non-invasive imaging techniques like CT-RadScore can characterize the tumor microenvironment, linking radiologic features to immune activity and clinical outcomes.
