Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy - Takeaways - MDSpire

Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy

  • By

  • Vincent Lo Re

  • Dean M Carbonari

  • Craig W Newcomb

  • Jessie Torgersen

  • Erica J Weinstein

  • Shanae M Smith

  • Katherine L Brecker

  • X Sherry Liu

  • Jay R Kostman

  • Stacey Trooskin

  • Rebecca A Hubbard

  • Joshua F Baker

  • Babette S Zemel

  • Mary B Leonard

  • September 15, 2025

  • 0 min

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  • 1

    Cure of hepatitis C virus (HCV) with direct-acting antivirals (DAAs) does not significantly improve bone microarchitecture after 18 months.

  • 2

    Participants with cured HCV showed significant decreases in inflammatory cytokines IL-18 and TNF-α compared to controls.

  • 3

    No significant differences were found in bone measurements between cured HCV participants and controls after adjusting for confounding factors.

  • 4

    Chronic HCV infection is associated with lower bone mineral density and increased fracture rates, necessitating potential BMD screening.

  • 5

    The study utilized high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess bone health in HCV-infected individuals.

Original Source(s)

Changes in Bone Microarchitecture and Inflammatory Cytokines After Cure of Chronic Hepatitis C Infection With Direct-Acting Antiviral Therapy

  • by Vincent Lo Re, Dean M Carbonari, Craig W Newcomb, Jessie Torgersen, Erica J Weinstein, Shanae M Smith, Katherine L Brecker, X Sherry Liu, Jay R Kostman, Stacey Trooskin, Rebecca A Hubbard, Joshua F Baker, Babette S Zemel, Mary B Leonard

  • September 15, 2025

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