The molecular diagnostic yield of frame-based stereotactic biopsies in the age of precision neuro-oncology: a cross-sectional study - Takeaways - MDSpire

The molecular diagnostic yield of frame-based stereotactic biopsies in the age of precision neuro-oncology: a cross-sectional study

  • By

  • Obada T. Alhalabi

  • Felix Sahm

  • Andreas W. Unterberg

  • Martin Jakobs

  • August 9, 2023

  • 0 min

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  • 1

    Stereotactic biopsies are crucial for diagnosing unclear, deep-seated intracranial lesions, particularly when resection is not feasible.

  • 2

    Next-generation sequencing and methylation studies have transformed brain tumor diagnostics, integrating molecular data with histopathology.

  • 3

    This study assessed the diagnostic yield of frame-based stereotactic biopsies in a high-throughput neuro-oncology center focusing on molecular genetics.

  • 4

    A total of 145 patients were included, with gliomas being the most common suspected diagnosis prior to biopsy.

  • 5

    Final diagnoses confirmed gliomas in 63%, lymphomas in 16%, and inflammatory diseases in 10% of the cases after biopsy.

Original Source(s)

The molecular diagnostic yield of frame-based stereotactic biopsies in the age of precision neuro-oncology: a cross-sectional study

  • by Obada T. Alhalabi, Felix Sahm, Andreas W. Unterberg, Martin Jakobs

  • August 9, 2023

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