Case Report: pulmonary MALT lymphoma with BIRC3::MALT1 fusion and indeterminate PET/CT findings - Takeaways - MDSpire

Case Report: pulmonary MALT lymphoma with BIRC3::MALT1 fusion and indeterminate PET/CT findings

  • By

  • Hongliang Zhang

  • Helun Cai

  • July 17, 2026

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  • 1

    Pulmonary MALT lymphoma is an indolent B-cell lymphoma that can mimic other diseases, complicating diagnosis and staging.

  • 2

    A 49-year-old man underwent surgery for a pulmonary nodule, with histopathology confirming pulmonary MALT lymphoma and a BIRC3::MALT1 fusion.

  • 3

    Postoperative PET/CT showed mild FDG uptake in longstanding pulmonary opacities, raising concerns for additional disease.

  • 4

    Longitudinal imaging indicated that the right-lung ground-glass opacities were stable and predated surgery by several years.

  • 5

    Histopathology, molecular testing, and imaging should be integrated to accurately assess disease extent and treatment response.

Original Source(s)

Case Report: pulmonary MALT lymphoma with BIRC3::MALT1 fusion and indeterminate PET/CT findings

  • by Hongliang Zhang, Helun Cai

  • July 17, 2026

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